Direct asymmetric Mannich reaction of phthalides: facile access to chiral substituted isoquinolines and isoquinolinones.
نویسندگان
چکیده
The first Mannich reaction employing phthalides using a quinidine-based multifunctional catalyst has been developed. The reported method led to the synthesis of 3,3-disubstituted phthalide derivatives in excellent yields, with good diastereo- and enantioselectivities. Convenient synthesis of chiral isoquinolinones and isoquinolines has also been demonstrated.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 39 شماره
صفحات -
تاریخ انتشار 2012